SAFETY
The safety of TIBSOVO was evaluated in a patient population with difficult-to-treat disease2

BOXED WARNING: Patients treated with TIBSOVO have experienced symptoms of differentiation syndrome, which can be fatal if not treated. TIBSOVO is associated with the following Warnings and Precautions: differentiation syndrome, QTc prolongation, and Guillain-Barré syndrome.

A TARGETED APPROACH
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Learn about a targeted approach to treating newly diagnosed and R/R AML with IDH1 mutations

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Learn about a targeted approach to treating R/R AML with IDH1 mutations

ONCE-DAILY ORAL DOSING
TIBSOVO offers convenient, once-daily oral dosing and can be taken at home.2

DISCOVER

the importance of IDH1 testing at diagnosis and relapse

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SUPPORT

with myAgiosTM Patient Support Services for access and financial assistance

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More than 1000 patients have been treated with TIBSOVO since FDA approval in July 20183

CR, complete remission, defined as <5% blasts in the bone marrow, no evidence of disease, and full recovery of peripheral blood counts (platelets >100,000/microliter and absolute neutrophil counts >1000/microliter); CRh, complete remission with partial hematological recovery, defined as <5% blasts in the bone marrow, no evidence of disease, and partial recovery of peripheral blood counts (platelets >50,000/microliter and absolute neutrophil counts >500/microliter); HMA, hypomethylating agent; IC, intensive chemotherapy; R/R, relapsed or refractory; RBC, red blood cell.2

References: 1. Molenaar RJ, Maciejewski JP, Wilmink JW, van Noorden CJF. Wild-type and mutated IDH1/2 enzymes and therapy responses. Oncogene. 2018;37(15):1949-1960. doi: 10.1038/s41388-017-0077-z 2. Tibsovo. Package insert. Servier Pharmaceuticals LLC; 2021. 3. Data on file. Servier Pharmaceuticals LLC.
 
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INDICATIONS

TIBSOVO is an isocitrate dehydrogenase-1 (IDH1) inhibitor indicated for the treatment of adult patients with a susceptible IDH1 mutation as detected by an FDA-approved test with:

Acute Myeloid Leukemia (AML)

  • Newly-diagnosed AML who are ≥ 75 years old or who have comorbidities that preclude use of intensive induction chemotherapy.
  • Relapsed or refractory AML.
Indications & Important Safety Information

IMPORTANT SAFETY INFORMATION

WARNING: DIFFERENTIATION SYNDROME IN AML

Patients treated with TIBSOVO have experienced symptoms of differentiation syndrome, which can be fatal if not treated. Symptoms may include fever, dyspnea, hypoxia, pulmonary infiltrates, pleural or pericardial effusions, rapid weight gain or peripheral edema, hypotension, and hepatic, renal, or multi-organ dysfunction. If differentiation syndrome is suspected, initiate corticosteroid therapy and hemodynamic monitoring until symptom resolution.

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